• Lonjevity Team

LCHiFi: new studies march 2018

Updated: Apr 4, 2018

Two studies just published reinforce the low carb high fibre mantra:

Yet more evidence of harm from high glycemic carbs and the hyperglycemia-insulin chain reaction from the study by Thaiss et al, Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection : Take home point excerpted here: Serum glucose is among the most strictly controlled physiological variables of organismal homeostasis. Chronically elevated glucose levels, as observed in diabetes mellitus, obesity and associated metabolic disorders, such as non-alcoholic fatty liver disease, result from altered homeostatic set points of the tightly regulated normoglycemic levels (33). Longstanding hyperglycemia, in turn, leads to a myriad of potentially devastating biochemical and physiological consequences, such as the generation of advanced glycation end products, pancreatic glucose toxicity (34, 35), macrovascular and microvascular complications impacting virtually every organ (36), risk of infection (37), and enhanced mortality (38). In this study, we have identified glucose as an orchestra-tor of intestinal barrier function. Hyperglycemia markedly interfered with homeostatic epithelial integrity, leading to abnormal influx of immune-stimulatory microbial products and a propensity for systemic spread of enteric pathogens.


A DIVERSITY OF FIBER was used by Zhao et al published in Science 9/3/2018: Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. This study on patients with diabetes showed a high fiber diet dramatically improved diabetes by increasing production of short chain fatty acids and raising blood levels of the miracle hormone GLP1.

The remarkable cure rate of type 2 diabetes by gastric bypass surgery is attributed largely to the 10 to 15 fold increase in GLP1 after surgery. GLP1 is produced in the hind gut in response to nutrients including short chain fatty acids produced from intestinal fermentation of fiber. The study by Zhao et al did not employ a low carb approach but nevertheless achieved remarkable results. A high fiber diet as well as low carbohydrates with chronically low glucose and insulin levels is likely to be even more effective in the prevention of metabolic syndrome, obesity and diabetes.